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KMID : 0616120070380030227
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 3 p.227 ~ p.233
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Cytotoxic constituents from the stem of Rhododendron mucronulatum
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Hong He-Sun
Kwon Yong-Soo
Jeon Seung-Ho
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Abstract
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Seven compounds were isolated from the n-BuOH soluble fraction of stem of Rhododendron mucronulatum as cytotoxic principles against brine shrimp lethality test. On the basis of spectral data, seven compounds were identified as (?)-catechin (1), (+)-epicatechin (2), taxifolin (3), scopoletin (4), quercetin (5), taxifolin-3-O-α-L- arabinopyranoside (6), and astragalin (7). Among tested compounds, taxifolin-3-O-α-L-arabinopyranoside (6) exhibited potent activity with LC50 value at 4.6 μg/ml.
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KEYWORD
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Cytotoxiciy, Rhododendron mucronulatum, brine shrimp lethality test, taxifolin-3-O-α-L-arabinopyranoside
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